Plants have served as the fundamental basis for the human pharmacopoeia since ancient times. There are an estimated 374,000 species of plants on Earth and roughly 9% of all plant life (33,000 species) have been used in some form of traditional medicine. Although the legacy of plants as sources of medicine is long, we have only recently begun to apply modern scientific tools to uncovering how botanicals work in mitigating skin disease. Dr. Quave searches the world for plants used in traditional systems of medicine to treat infectious and inflammatory skin diseases, including skin and soft tissue infections, acne, and atopic dermatitis. She offers insights from her research conducted on more than 700 medicinal plant species and explores some of the different ways plant-derived natural products influence skin health through manipulation of the skin microbiome.